The Neapolitan Mastiff is an endearing breed of dog with a regal stature. With its massive head and droopy jowls, it has no problem catching the eye of all who see it. Obtaining a Neo can be quite costly; because if this, they are not as commonly seen compared to other types of dog. When out in public, a well socialized Neo is friendly, calm and very open to meeting new people. Many are fascinated with the breed and its delightful physique. While their weight and temperament are often at the center of conversation, there are a few other prudent traits of the Neo that frequently get left out.

As many an owner has come to find, the Neapolitan Mastiff is a mammoth dog with mammoth levels of flatulence. While this is a common aspect of dog ownership in general, many new owners find themselves quite unprepared for the Neo's gassy capacity. Since the passing of gas is a normal body function, there is rarely anything that can be done to prevent flatulence altogether; however, when it is excessive, breeders recommend taking a look at the protein levels in daily meals. A protein content that is too high can often cause problems with gas. Gulping in air during feedings can also be a problem. Owners should always feed their Neo in a calm setting that does not make them feel rushed to eat their food.

When eating or drinking, the heavy jowls on the Neapolitan Mastiff can drip with slobber and drool. The new Neo owner will quickly learn to stash absorbent drool rags throughout their home. Those who are uncomfortable with the idea of slobber hitting the walls or splashing across furniture when the Neo shakes its head may want to opt for a different breed. Slobbering is simply a trait that is every bit part of the breed as its ears and tail. Though it is not constant, many Neo's will drool while they are eating or sleeping, prompting many owners to ban their colossal companion from the bed. Though some say chew toys can help the Neo swallow more of their saliva, others insist it only further promotes the production of slobber.

Besides drooling in their sleep, the Neapolitan Mastiff also snores. This can sound like an endearing trait until one has to hear the ear splitting level these snores can occasionally reach. The breed's bone structure and heavy jowls simply create the perfect environment for a loud reverberating snore. Those who insist on quiet or sleep light during the night, may also want to opt for another breed. The majority of Neo owners actually come to find this trait quite charming. Some Neo's have also been known to make almost human sounding vocalizations asking for treats and goodies for time to time.