Black Hair Follicular Dysplasia
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If your dog has a multicolored coat then it may be susceptible to a rare condition known as Black Hair Follicular Dysplasia, or BHFD. A hereditary disorder carried through recessive genes, BHFD can appear in any purebred or crossbreed dog with a multi-colored coat. An as-yet-unidentified genetic defect in the skin pigment (melanin) and in the hair shaft formation is believed to be the cause.
This condition causes the black or dark-haired portions of the coat to fall out when the animal is still a puppy or young dog, leaving behind bare skin. In the early stages, the pup's dark hair will gradually fade and take on a washed-out, gray or bluish cast. [...]