Cervical Vertebral Instability
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One of the more catastrophic ailments that can affect your large-breed dog is a condition known as Wobbler Syndrome, or clinically as cervical vertebral instability.
This syndrome occurs when the spinal cord is compressed in the cervical (neck) area. This compression, or pinching, happens because the vertebra through which the cord passes is malformed or misaligned. The compression injures the part of the spinal cord that's necessary for an animal to stand and/or move normally.
What causes these deformities in the vertebrae isn't yet known, but it is believed to be related to both genetics and nutrition. In some young dogs, Wobbler can develop if the animal is fed a diet excessively high in protein, calcium and phosphorus, in an attempt to accelerate the growth process. This is believed to cause the skeletal changes that occur in some affected dogs. [...]