I have seen it used twice, and both times when the dog was having the series of needles , they shook, but the vet took them out,and walked them and they stopped shaking. Any vet will tell you it's not easy on a dog's system, but sometimes it's the best alternative. I know in certain parts of the U'S vets won't administer the shot, saying it's too dangerous. If that were the case there would be a whole pile of dead cows and horses - that is what it is commonly used on. I believe the benefits outweigh the risks, especially if the bitch is a champion show dog, and a much bigger dog bred her. This actually happened. The bitch was a poodle having a silent heat, and the young man who took a shine to her was a Dalmation.
In 1992 I was showing two of my Bullmastiffs in conformation. The bitch, Little Bit, was only 14 months old and almost finished when she came into her first heat. I did not want her bred and put my male, Bruno, in the kennel building and kept her in the house. I woke up on a Saturday morning and didn't see Little Bit in the house and asked my 8 year old daughter where she was. My daughter said" I think Bruno is lonesome so I put her in the kennel with him." I called my vet and I told him what had happened. He said he had never heard of a breeding taking that late in the heat cycle and didn't want to do a miss-mate shot because of the risk involved and the fact that at some point I did want to breed her. Well she had 12 puppies via emergency c-section and all but 3 died, she hated them and didn't want to feed them and was never enthused about any of her later litters of pups. I would rather take my chances with a miss- mate shot, than go thru that experience again.
The consensus on Showdogs-L whenever it comes up is no. Many people have used it, many people have had bitches who have gone pyo on subsequent heats. The only advice people really have is if you use the shot, you should purposely breed next heat to keep hormones in check. People mainly let the pregnancy occur or spay the bitch to terminate it. But, if it is your champion dog.. spaying is pretty far from ideal. Pyo is pretty miserable though.. and I wouldn't be doing anything that could up my chances of it occurring.
~I'm changing my naughty ways to naughtier ones..~
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DroghedaBullmastiff, I'm sorry you had to go through that awful experience because of a vet who did'nt know what he was talking about. Lutalyse is a prostaglandin F2Alpha, and is commonly used all over Canada to determine the cycles of mares, abort feedlot cows, etc, etc. It is also commonly used by the muscle-bound nimrods who think they look so much more attractive after injecting it to really pack on the beef. I really disagree with those vets who are opposed to it. I would never recommend it as a 'morning after' fix, but in certain situations, it really could help the dog in question.