There's not a lot you can do to make your dog more comfortable, other than the normal daily care you provide her with. You can make sure she's not too hot if you live in a hot humid place, and provide her with plenty of fresh drinking water. You can buy little doggy panties to keep her from messing up your house, and perhaps give her a bath once a week. I'm sure you know it's of the utmost importance to keep her solidly locked away from all male dogs, as they have been known to break down doors, and breed through fences. Make sure you keep her seperated for the whole cycle. Good luck with her, she'll be fine!