Seems Noromectin is just a brand name and not a different drug, like Advil is the brand name for ibuprofen.
If you want to give an accurate dose like Rednevaj said, just remember that on a 1cc/ml insulin syringe, each individual black line equals 2 units. So to give a dose for a 72lb dog you would go one tiny line past the 70 mark and not 2 lines. For a 25lb dog you would go 2 lines past the 20 mark and not 5 lines. That will dose for 24lbs and I think that will be close enough.
>I just bought a bottle of Noromectin 1% to use as heartworm preventative for my two dogs.<
Noromectin 1% injection and Ivomec 1% injection are the same drug, just compare labels.
****Do not use Noromectin Plus as it contains chemicals that may harm your dog .****
You have been given good advice by knowledgeable folks here on this forum. The dosing that oxford uses has been around for years, used by much of the farming community and was published in the mid eighties in a beagle dog health guide if my memory serves me correctly. If your dog is a breed that can take ivermectin you are in luck as there are other off label uses as well at differing dose schedules. If you consider Heartgard by Merial the gold standard for HW prevention please read on for small dog application.
Dosing for dog 1 to 25 pounds. 68 mcg. Dosing for dog 26 to 50. 136 mcg. Dosing for dog 51 to 100 pounds. 272 mcg.
As you can see there is a wide safety range for this drug as dogs at the lower end of a weight range receive much more ivermectin than dogs at the top end. Having said this notice that FDA approved HW prevention dosing is in micrograms(mcg). Heartgard uses 2.72mcg. per pound as their upper control point , so , small dogs sometimes get significantly more than 2.72mcg. per pound in a given weight range. --------------------------------------------------------------------------------------------------------------------- Noromectin 1% injection straight out of the bottle has 10 mg of ivermectin per ml/cc. One ml/cc of Noromectin 1% injection contains 10 mg. / 10,000 mcg. Ivermectin. One tenth (1/10) ml/cc Noromectin 1% contains 1mg. /1,000mcg. Ivermectin.
It is hard to measure less than 1/10 ml/cc. , so , for the small dog of say 20 pounds or less using the Heartgard dose of 68 mcg. ivermectin , it would make sense to dilute the Noromectin 1% injection.
Use food grade propylene glycol ( order from local independent pharmacy) to dilute Noromectin.
***** Do Not Use Ethylene Glycol ( antifreeze ) as this is POISON and will KILL The Dog *****
Go to local pharmacy and pick up a new 120 ml plastic bottle, they will prolly give it to you.
Fill with food grade propylene glycol to 99 ml/cc eyeball just under the 100 ml/cc mark. Draw up 1 ml/cc Noromectin 1% injection and add to the 99 ml/cc of propylene glycol in the bottle. Always clean rubber top on Noromectin w/alcohol, let dry and use throw away syringes graduated in ml/cc
You have 1 ml/cc Noromectin 1% ( 10 mg ivermectin ) now in 99 ml/cc of proplene glycol for a total of 100 ml/cc.
10mg Noromectin divided by total solution of 100ml = 0.1 mg or 100 mcg ivermectin per ml/cc.
To dose the small dog using the Heartgard schedule of 68 mcg. just draw up .7 ml/cc or 7/10 ml/cc of diluted Noromectin 1% and you have 70 mcg. (micrograms) of ivermectin.
hope this helps , oldhounddog
***Edited By: oldhounddog on 10/7/2010 10:04:28 PM*** Reason: ivermectin dosing
Thank you for the comments posted in the forum. The information was greatly helpful in my research on the dosage of Ivermectin. We are heartworm free, and continue to be with the continued use of Ivermectin. Recently it has been questionable as to whether to continue treatment with the monthly regimen that is so costly. The only certain thing was that the use of the drug works. Proven 7 yrs heartworm free after once being tested positive. With so many alternatives and new information given uncertainty led the pathway here. Once decision had been made to begin dosing with the brand name Noromectin 1% it became a must to get the accurate dosage to administer. Contacting the drug company, my vet, and a pharmacist were only giving bits of information on the dose to be given. Reason being not wanting to be liable for lawsuit. FDA does not recognize Noromectin 1% as method of administering Ivermectin to dogs. It is approved for cattle and swine. When I question this I was told that the dosage has to be calculated. Thus little help was available. Persistence is a key in obtaining knowledge. Researching blogs and forums from the many online sites educated me. Many times it's stated Noromectin works, but the doses were incorrect. The posted information of diluting to 9:1 or 30:1 ratio clarified the fact that .1cc per 10 pounds of body weight was indeed overdosing. My math & common sense told me that much, so thanks for that post of diluting and giving the doses per weight. Great write up. Thanks!
my BestestFriend is a DOG... He taught me well. ~Depend On God~
I just went to the vet because I got lice in my kennel and he had me give 1/2 cc per 4 pounds of dogs and even that to my puppies only 2 weeks old.Says right on my bill Noromectin 50ml.So am I ovrdoseing all my dogs??What are the symptoms?
My purebred Brittany got 6 mg of a 10% solution of noromectin and very nearly died. Severe ataxia that lasted almost 12 hours.
I would suggest using this medication only with a vet and only then after full discussion of possible side effects. If your vet says it can only happen to collies or some such thing tell them you would like to err on the side of caution and test for sensitivity. Cooties won't kill him overnite. This could.
I have been using Ivomec for 20 years on my dogs and this is how I do it and I haven't hurt nor killed one of them yet. No, a few drops is NOT an exact measurement, but if you fill a syringe to the 0.2cc line, it will equal around 4-5 drops of medicine. I have worked this formula out many times to ensure it's accuracy and I also work with my vet regarding what and how much I am giving.