I've been doing excessive internet research and have bugged my vet to death about it, and I thought I would post here to get any info and/or advice from anyone who has had experience with this. Thanks in advance...
My 11 year old spayed lab mix has just been diagnosed with ATYPICAL CUSHINGS.
Over the past year or so she has had elevated liver enzymes, a growth by her kidney, and a few urinary infections. The vet recommended we give her SAM-e and milk thistle and just keep an eye on via regular blood work and ultrasounds. After another recent urinary infection, and higher liver enzyme levels, another ultrasound was done, which revealed that the kidney growth was larger and the liver lobes more swollen.
Last Tuesday she was cut open and biopsies of her liver and a growth near her kidney were taken. She is cancer free and the diagnosis is Atypical Cushings. Her previous Cushings test was inconclusive. It was revealed that the growth by the kidney is benign and is actually on the adrenal gland, which is causing the Cushings, which is then adversely affecting the liver.
Currently, a week post-op, her incision site is healing nicely and she is on antibiotic (Cephalexin) and pain pills (Tramadol) 3x/day each. Over the weekend she had an anal gland that almost abscessed and had to be drained and some bladder inconinence. Other than her system seeming to be completely whack from all she has had going on lately, she appears to be almost back to normal. Tail wagging, playful, greeting me when I come home from work.
That's her history and what has been going on lately. Sorry for the novel. I understand if many of you stopped reading by now. lol
The vet prescribed Trilostane (80 mg/ml) liquid solution at 1 ml once per day. She started her first dose of the med early yesterday morning (at 6 AM). This morning she threw up her breakfast (shortly before 6 AM) so I held off on giving her the Trilostane until her lunch feeding. I decided not to give her her painkiller at lunch because I don't think she is in pain anymore and I wanted to give her system a little break from so much medication. I discussed all this with her vet and we are hoping the vomit was a coincidence and not a reaction to the Trilostane. Shouldn't 24 hours be enough time for the drug to be out of her system anyway? Since I gave the Trilostane at lunch she has acted fine so far (knock on wood).
Does anyone have experience with Cushings/Trilostane/any other thing I mentioned. Any advice/help/info is much appreciated. This is my child and I want to do all I can to help her.
Hi. Sorry to read that your dog is going through a rough patch.
We had a Shih Tzu, named Petey, that was diagnosed with Cushings at the age of 3 or 4. He survived until just past his 13th birthday. Petey was also on the same drug but capsule form. We were told to give it to him after dinner, when he had a full stomach. He never had a problem taking the pill.
From your discription of your dogs surgery, it sounded like the tumor on the adrenal gland was removed. Petey's tumor was on his pituitary gland and unoperable. I was under the impression that that if the tumor was removed, the Cushings would resolve itself.
We felt the same way you do about our Petey. He passed away almost two years ago. Our daughter is 24 now and planning on moving out in January. So, my husband and I are preparing for the empty nest and looking for a puppy. That is how I found your message. If you need any more info, I'll try to help you if I can.
We live outside of Phila. We took Petey to the UofP Veteranary Hospital for diagnosis. Petey also had chronic skin problems, ear infections, glaucoma and eye infections. But, he was pretty happy up until the last year. He got old fast his last year. It was really hard. And, cost us a fortune.
We also had a cat, named Milo, that our daughter found when he was 2 weeks old and bottle fed him. He turned out to be sickly, too. Petey died in April 2010, and Milo died of a massive stroke last Dec. 23. Milo was only six, but he was a hugh cat. He was more than 2x's the size of Petey, but they both weighed 22 lbs. Milo loved Petey, but Petey was too old and used to being the baby when Milo came to live with us. He just ignored Milo unless he was cold, then he would snuggle with Milo. God, we miss them.
Sorry, I kind of got off track. Ask your Vet about whether removing that tumor has any effect on the Cushings. We had to have Petey's cortisin level tested at least once a year to make sure he was on the right dose of medicine.
I'm sorry to hear about both your babies. It is reassuring to hear of your success story with Petey and his Cushings. Thanks for that. That's a long life, especially with a disease diagnosis at such a young age. Best of luck with your new puppy. That should keep you so busy you don't notice the empty nest! :)
No, Cinna's tumor is not operable. Her vet said it is benign and not worth removing. He said is is ~3.5 cm and is touching the kidney so he would likely have to remove the kidney too if he removed the tumor. He's worried about its proximity to the renal artery too. He said it would be difficult and feels he can just treat it with Trilostane and hopefully after a while her liver enzyme values would drop and the swelling would go down. Of course this disease can't be cured but he thinks her liver can recover to an extent with treatment.
I am just so ready for her to be off this antibiotic and painkiller and be completely recovered from her surgery so the Trilostane can really start to do its thing she she can start to improve. I just hate all the different variables involved right now. If she gets sick or has bladder leakage I don't know which med is causing it. I am weaning her off the pain killer now since it's been a week and she doesn't seem to be in any pain.
Anyway, I'm rambling. Thanks so much for responding. Hopefully this treatment will be a sucess for her as it was for Petey. We wish they could all just live forever, don't we.