As a breed that sheds regularly, taking care of the American Eskimo's coat is a subject of great importance. An Eskie that is allowed to go without grooming can not only end up with mats but stomach upset and blockages from swallowing too much of its own hair. The thick double coat of the Eskie serves a unique purpose that requires a certain amount of care and maintenance. With such a unique white coat, there are things that must be done and cannot be done to an Eskie's coat. Plus, grooming not only creates a strong bond; it also makes it easier to keep a household fur free and hygienic.

Many professionals recommend using a medium to coarse bristled brush or comb for an Eskie's coat. To help with the smaller areas on the body, a small slicker brush is also recommended. Because brushing an Eskie's coat sometimes gives off static electricity, groomers are known to make use of a misting bottle that contains part water and part hair conditioner for dogs. Hair conditioner for dogs can be found at any pet or grooming supply shop. Misting the hair lightly can make grooming a much easier process for both the owner and the Eskie. It is important to completely comb an Eskie before bathing; otherwise, the thick undercoat can mat up once exposed to water.

It should be noted that the coat of an Eskie is waterproof and will take some time to thoroughly wet down. After shampoo is applied and rinsed, it is extremely important to ensure that all soap is removed from the coat without a doubt. The skin of the Eskie is one that does not take much to become raw and irritated. The breed is very well known for having a negative reaction to fleas that leads to scratching that in turn leads to hotspots and other skin sores. Groomers recommend gently squeezing the coat until only clear water pours out. Following with a light conditioner helps add shine and prevent tangles.

An Eskie should be towel dried right away, using a stiff comb to deftly get through hair. During warm summer months many choose to simply towel dry. In cooler winter months, owners can use a hair dryer set on low or warm to help speed up the drying process. The insulating undercoat of the Eskie usually keeps them warm; however, when it is wet it can make them feel somewhat chilled. It is important to first accustom an Eskie to the noise and air flow of a hair dryer; otherwise, they can be traumatized and grooming time can become an all out battle. When using a hair dryer it is essential to distribute the airflow evenly as not to burn or scorch the Eskie's hair or skin.