hey,
I just got a Pastel Calico kitten, name Penelope. Sh loves to be petted as well as played with.
I just want some tips on how to handle cats, this is the first cat I have ever owned.
Thank You

IMO, there is no real right way to handle. Whatever comes natural is usually right. Kittens are pretty crazy and have tons of energy. So try to direct that energy positively rather than letting it develop bad habits while trying to entertain itself (ie tearing up your stuff). The only other big thing is socialization. The envirnoment it gets comfortable with now will determine behavior later. If it is never around people and noise, it may be scared of those situations later. Socialize him as much as possible. Here is a little article from petcentric on that:

http://www.petcentric.com/Stories/Articles/Scaredy-Cats.aspx?articleid=bda82502-cf20-4438-bef7-92e9e44b35f8

First, kittens are out of their minds! lol

Everything is practice for hunting they will run at with their backs arched sideways, tails puffed. Lots of flopping around and "kill moves". They like boxes to climb into. Lots of dangler toys.
In my opinion, get your cat used to affection, getting brushed, bathed and nails clipped/dremeled young. You can see the quick on a cat nail fairly well.

Scoop away clumping litter is a good brand. Feed her a high quality kitten food until she is a year. You shouldn't feed them cow milk, it can upset their stomach.

Congratulations, cats are the coolest.